恶性血液病危险因素病例对照研究

目的了解恶性血液病患者发病的危险因素。方法采用1：1配对病例对照研究方法，对150例恶性血液病人及150例健康对照进行问卷调查，使用条件Logistic回归模型进行分析。结果居室装修3年及以上（OR=60．89）、住所临近繁忙交通要道（OR=5．172）或化工厂（OR=25．257）、化学胶接触史（OR=13．522）、汽油接触史（OR=7．486）、农药接触史（OR=4．421）、父亲生育前饮酒吸烟（OR=2．259）、母亲生育年龄30～35岁（OR=5．891）等因素与血液病发生的差异均有统计学意义。结论恶性血液病的发生与室内外空气污染、有害物质接触史、父亲生育前饮酒吸烟、母亲生育年龄高等因素有关，应积极控制危险因素，以减少恶性血液病的发病率。

Case control study on risk factors of malign blood system disease

Objective To know risk factors of malign blood system disease.Methods A case-control study was conducted,150 cases of malign blood system disease and 150 health controls were surveyed by questionnaire.Conditional Logistic regression model was used to analyze risk factors.Results Home decoration for 3 years or more(OR=60.89),busy roads nearby the home(OR=5.172),chemical plant nearby the home(OR=25.257),chemical glue contact history(OR=13.522),petrol contact history(OR=7.486),agricnltural chemical contact history(OR=4.421),father drink and smoke before pregnancy(OR=2.259),high age of pregnancy(OR=5.891) were the risk factors of malign blood system disease.Conclusion The development of malign blood system disease was related to environmental air pollution,harmful substance contact history and parents influence factors.Strengthening the control of the risk factors was suggested to reduce the incidence of malign blood system disease.