| 肺癌的细胞遗传学初步研究 |
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| 引用本文： | 方嬿,卓子兰,梁启万,区宝祥.肺癌的细胞遗传学初步研究[J].中山大学学报(医学科学版),1986(3). |
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| 作者姓名： | 方嬿 卓子兰 梁启万 区宝祥 |
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| 作者单位： | 中山医科大学肿瘤研究所
(方嬿，卓子兰，梁启万)，中山医科大学肿瘤研究所(区宝祥) |
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| 摘 要： | 我们用细胞遗传学方法分析了6例肺癌患者原发肿瘤的G带染色体,结果表明:6例肿瘤均有染色体数目和结构异常;染色体数目分布范围广(从38～180),除1例染色体众数是亚二倍体外,其余各例均为高异倍体。结构方面:每例有3～4个标记染色体和各种异常染色体,其中1q等臂染色体是出现频率较多的标记染包体(4/6),1p等臂染色体亦在3例中可见,其次受累的染色体是3、5、9、11、13号等。 虽然1号染色体的变化与多种肿瘤有关,而在肺癌方面更似有明显的关系,其断裂点在1q~(11)或1p~(11),断裂后形成恒定的标记染色体。我们提出:1q~(11)和1p~(11)的断裂与肺癌的发生有一定的联系。
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| 关 键 词： | 肺癌 染色体 断裂热点 1q~(11)1p~(11) |
Chromosome Studies on Humon Lung Cancer |
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| Fand Yan Zhuo Zhilan Liang Qiwan Ou Baoxiang.Chromosome Studies on Humon Lung Cancer[J].Journal of Sun Yatsen University(Medical Sciences),1986(3). |
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| Authors: | Fand Yan Zhuo Zhilan Liang Qiwan Ou Baoxiang |
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| Institution: | Cancer Institute |
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| Abstract: | Some human tumors are characterized by specific chromosome changes. We have analyzed cytogenetically the primary tumors from 6 patients with lung cancer. The G-banding techniques were used for analysis of karyotypes.
The results showed that numerical and structural abnormalities of chromosome were found in all 6 cases. Structural and numerical involvements affected most commonly chromosome #1 (5/ 6)> chromosome #9 (3/6) and chromosome #11n (3/6). There are three or four makers chrcmosome and many kinds of abnormalities chromosome in every cases.
Our preliminary results suggested that abnomalities of chromosome #1 may play a key role in the expression of the lung oncogene and 1q11 or1p11 may be the breakpoints of lung cancer. |
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| Keywords: | lung cancer chromosome breakpoint 1q~(11)1p~(11) |
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