5 a以上肾移植患者环孢素血药浓度监测的临床分析

目的分析带肾存活5a以上肾移植患者环孢素（CsA）gn药浓度监测的临床意义。方法采用荧光偏振免疫法（mA）测定112例肾移植患者2530例次CsA血药浓度，并对其术后时间、性别、免疫抑制方案、CsA谷浓度（c0）、服药后2h血药浓度（c2）等进行统计分析。结果血药浓度随术后时间的延长而逐渐下降，且个体差异较大；男女2组血药浓度差异未见有明显统计学意义（P〉0.05）；2种免疫抑制方案中，CsA的用药剂量与血药浓度差异分别呈明显统计学意义（P〈0.05）。结论监测CsA血药浓度，可防止免疫过度、不足和药物毒性，从而提高移植肾的长期存活率。

Clinical study of the blood concentration monitoring for cyclosporine in renal transplant recipient with functional renal allograft more than five years

AIM To explore the blood concentration monitoring of ciclosporin (CsA) in renal transplantation recipient with functional renal allograft more than 5 a.METHODS The concentration of CsA of 112 patients(2 530 cases) was determined by FPIA method. Factors such as renal transplantation time ,sex, immunosuppressive therapy [CsA +mycophenolate mofetil(MMF)+prednisone (Pred), CsA+azathioprine (Aza)+Pred],concentration(c_0/c_2) of CsA were analyzed.RESULTS The blood concentration of CsA was no significant difference in sex.There was significant difference in the dose and concentration of CsA between MMF group and Aza group (P<0.05). CONCLUSION It is necessary to monitor the blood concentration of CsA to aviod toxic responses of patients, to serve a useful purpose in controlling CsA therapy and to improve the patient/kidney survival rate.