Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma |
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Authors: | Schutt Christopher Bumm Klaus Mirandola Leonardo Bernardini Giovanni D'Cunha Nicholas Tijani Lukman Nguyen Diane Cordero Joehassin Jenkins Marjorie R Cobos Everardo Kast W Martin Chiriva-Internati Maurizio |
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Affiliation: | Division of Hematology & Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas 79430, USA. |
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Abstract: | Patients with squamous cell carcinoma of the head and neck (HNSCC) are usually treated by a multimodal approach with surgery and/or radiochemotherapy as the mainstay of local-regional treatment in cases with advanced disease. Both chemotherapy and radiation therapy have the disadvantage of causing severe side effects, while the clinical outcome of patients diagnosed with HNSCC has remained essentially unchanged over the last decade. The potential of immunotherapy is still largely unexplored. Here the authors review the current status of the art and discuss the future challenges in HNSCC treatment and prevention. |
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