| 肥胖对2型糖尿病一级亲属胰岛素抵抗、β细胞功能和超敏C反应蛋白水平的影响 |
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| 引用本文： | 陈小琳,李竞,文重远,孙永林,王颖,蔡小俐,周波,李珍瑾.肥胖对2型糖尿病一级亲属胰岛素抵抗、β细胞功能和超敏C反应蛋白水平的影响[J].中华内分泌代谢杂志,2008,24(5). |
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| 作者姓名： | 陈小琳 李竞 文重远 孙永林 王颖 蔡小俐 周波 李珍瑾 |
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| 作者单位： | 武汉大学人民医院内分泌科,430060 |
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| 基金项目： | 湖北省卫生厅科研项目 |
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| 摘 要： | 观察肥胖和非肥胖葡萄糖耐量正常的2型糖尿病一级亲属胰岛素敏感性、β细胞功能和血清超敏C反应蛋白(hs-CRP)水平,结果显示肥胖2型糖尿病一级亲属存在胰岛素抵抗、β细胞功能受损和hs-CRP水平升高,且胰岛素抵抗、hs-CRP与腰围正相关.
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| 关 键 词： | 肥胖症 糖尿病 2型 一级亲属 胰岛素抵抗 C反应蛋白质 |
Effects of obesity on insulin resistance, β-cell function and serum high-sensitivity C-reactive protein level in first-degree relatives of type 2 diabetic patients |
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| CHEN Xiao-lin,LI Jing,WEN Zhong-yuan,SUN Yong-lin,WANG Ying,CAI Xiao-li,ZHOU Bo,LI Zhen-jin.Effects of obesity on insulin resistance, β-cell function and serum high-sensitivity C-reactive protein level in first-degree relatives of type 2 diabetic patients[J].Chinese Journal of Endocrinology and Metabolism,2008,24(5). |
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| Authors: | CHEN Xiao-lin LI Jing WEN Zhong-yuan SUN Yong-lin WANG Ying CAI Xiao-li ZHOU Bo LI Zhen-jin |
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| Abstract: | Insulin sensitivity,β-cell function and serum high-sensitivity C-reactive protein (hs-CRP)levels were observed in obese and non-obese normoglycemic first-degree relatives of type 2 diabetic patients (FDR). The results showed that there existed insulin resistance,β-cell dysfunction and increased serum hs-CRP level in obese FDR of type 2 diabetic patients. Moreover, insulin resistance and increased CRP level were positively related to waist circumference. |
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| Keywords: | Obesity Diabetes mellitus type 2 First-degree relatives Insulin resistance C-reactive protein |
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