Parental occupation, occupational exposure to solvents and polycyclic aromatic hydrocarbons and risk of childhood brain tumors (Italy, France, Spain) |
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Authors: | S Cordier B Lefeuvre G Filippini R Peris-Bonet M Farinotti G Lovicu L Mandereau |
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Institution: | (1) Unit of Epidemiological and Statistical Research on Environment and Health, National Institute of Health and Medical Research (INSERM), Villejuif, France;(2) Istituto Neurologico C. Besta', Milan, Italy;(3) Universitat de Valencia, Valencia, Spain;(4) Istituto Neurologico C. Besta', Milan, Italy;(5) Istituto Neurologico C. Mondino', Pavia, Italy |
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Abstract: | The role of parental occupational exposure in childhood brain tumorswas investigated in a population-based case-control study grouping 251 casesand 601 controls from three European centers: Milan (Italy), Paris (France),and Valencia (Spain). Parental occupational exposure to solvents andpolycyclic aromatic hydrocarbons (PAH) during the five-year period beforebirth was estimated using a job-exposure matrix developed earlier in the samecountries. Odds ratios (OR) of brain tumors for each occupation andoccupational exposure were estimated by logistic regression, adjusting forchild s age, gender, exposure to tobacco smoke and ionizing radiation,mother s age and years of schooling, and center. The risk of childhood braintumors rose when fathers worked in agriculture (OR = 2.2, 95 percentconfidence interval CI] = 1.0-4.7) and motor-vehicle-related occupations. Inthe latter group, the risk increased for primitive neuroectodermal tumors inparticular (OR = 2.7, CI = 1.1-6. 6). Astroglial tumors were more frequentamong children of mothers in health services (OR = 2.2, CI = 1.0-4.9).Paternal exposure to PAHs was associated with an increased, but notdose-related, risk of primitive neuroectodermal tumors (OR = 2.0, CI =1.0-4.0), and maternal exposure to solvents at a high level was associatedwith an increased risk of both astroglial (OR = 2.3, CI = 0.9-5.8) andprimitive neuroectodermal tumors (OR = 3.2, CI = 1.0-10.3). |
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Keywords: | Brain neoplasms child Europe parental occupation polycyclic aromatic hydrocarbons solvents |
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