| AECOPD患者细胞黏附分子变化及其临床意义的研究 |
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| 引用本文： | 楼黎明,胡丹丹,董浙清,刘文兵,徐慧连.AECOPD患者细胞黏附分子变化及其临床意义的研究[J].现代实用医学,2011,23(5):501-502,506. |
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| 作者姓名： | 楼黎明 胡丹丹 董浙清 刘文兵 徐慧连 |
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| 作者单位： | 浙江中医药大学附属第三医院,杭州,310005 |
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| 基金项目： | 浙江省中医药科技计划项目 |
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| 摘 要： | 目的观察慢性阻塞性肺疾病急性加重期（AECOPD）患者血清E-选择素（E-selectin）和血管细胞黏附因子-1（VCAM-1）水平,以及银杏叶提取物（GBE）对其的影响。方法将60例AECOPD患者随机分为常规组和GBE组,各30例;并选择同期30例健康体检者作为对照组。两组基础治疗相同,GBE组每日加用舒血宁注射液20 ml静脉滴注,连用2周。应用酶联免疫吸附法检测血清E-selectin和VCAM-1的水平。两组均于入院第1天和治疗2周后行肺功能检查。结果治疗前常规组和GBE组E-selectin和VCAM-1水平均较对照组高（均〈0.01）;治疗后,两组E-selectin和VCAM-1水平均较治疗前显著降低（均〈0.05）,而GBE组较常规组下降更为显著（均〈0.05）。两组1 s用力呼气量预测值、1 s用力呼气量/用力肺活量均较治疗前高,GBE组较治疗前差异有统计学意义（均〈0.05）,而常规组治疗前后无显著差异。结论银杏叶提取物可明显降低AECOPD患者血清E-selectin和VCAM-1水平,改善肺功能。
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| 关 键 词： | 肺疾病 慢性阻塞性 银杏叶提取物 E-选择素 血管细胞黏附因子-1 |
Changes and clinical significance of serum cell adhesion molecules among patients with chronic obstructive pulmonary disease |
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| LOU Liming,HU Dandan,DONG Zheqing,LIU Wenbing,XU Huilian.Changes and clinical significance of serum cell adhesion molecules among patients with chronic obstructive pulmonary disease[J].Modern Practical Medicine,2011,23(5):501-502,506. |
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| Authors: | LOU Liming HU Dandan DONG Zheqing LIU Wenbing XU Huilian |
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| Institution: | LOU Liming*,HU Dandan,DONG Zheqing,LIU Wenbing,XU Huilian.(The Third Hospital Affiliated to Zhejiang Traditional Chinese Medical University,Hangzhou 310005,Zhejiang,China) |
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| Abstract: | Objective To investigate the influence of ginkgo biloba extract(GBE) on serum e-selectin and vascular cell adhesion molecules-1(VCAM-1) of patient swith chronic obstructive pulmonary disease(COPD) in acute exacer-bation.Methods Sixty patients with COPD at acute exacerbation stage were randomly divided into two groups: con-ventional treatment(CT) group and GBE treatment(GBE) group,with 30 cases in each group,and 30 healthy adults served as the controls.All COPD patients were given conventional treatment,whil... |
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| Keywords: | Pulmonary disease chronic obstructive Ginkgo biloba extract E-selectin VCAM-1 |
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