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| 五环三萜类柴胡皂苷单体抗耐红霉素金黄色葡萄球菌活性研究 | |
| 引用本文： | 姜淼,沈亮亮,叶元康,潘胜利,施伟民. 五环三萜类柴胡皂苷单体抗耐红霉素金黄色葡萄球菌活性研究[J]. 现代实用医学, 2011, 23(5): 498-500,F0002. DOI: 10.3969/j.issn.1671-0800.2011.05.008 |
| 作者姓名： | 姜淼 沈亮亮 叶元康 潘胜利 施伟民 |
| 作者单位： | 1. 上海市同济医院、同济大学附属同济医院,上海,200065 2. 复旦大学药学院 3. 上海市第一人民医院 |
| 基金项目： | 国家新药筛选中心横向基金资助项目 |
| 摘 要： | 目的探讨柴胡抗菌有效成分五环三萜类活性单体Bp3的抗耐红霉素金黄色葡萄球菌（ERSA）作用及其与红霉素的协同作用。方法参照美国临床实验室标准化委员会标准,测定Bp3对20株ERSA的最低抑菌浓度值（MIC）及其与红霉素的协同作用。结果 Bp3对ERSA的抑菌作用优于红霉素,且联合用药时显著减少了每一药物的MIC。20株耐红霉素黄色葡萄球菌均表现为协同或相加作用方式。结论结构明确的五环三萜类单体Bp3对ERSA有一定的抑制作用,且与红霉素有协同或相加作用。 |
| 关 键 词： | 中草药 单体 耐红霉素金黄色葡萄球菌 红霉素 体外抗菌活性 |
Effect of monomers of pentaeyclic triterpennoids of saikosaponines from Bupleurum kunmingense against erythromycin-resistant staphylococcus aureus |
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| JIANG Miao,SHEN Liangliang,YE Yuankang,PAN Shengli,SHI Weimin. Effect of monomers of pentaeyclic triterpennoids of saikosaponines from Bupleurum kunmingense against erythromycin-resistant staphylococcus aureus[J]. Modern Practical Medicine, 2011, 23(5): 498-500,F0002. DOI: 10.3969/j.issn.1671-0800.2011.05.008 | |
| Authors: | JIANG Miao SHEN Liangliang YE Yuankang PAN Shengli SHI Weimin |
| Affiliation: | JIANG Miao,SHEN Liangliang*,YE Yuankang,PAN Shengli,SHI Weimin(Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China) |
| Abstract: | Objective To discuss the antimicrobial activity of monomers named pentaeyclic triterpennoids(Bp3).Methods According to the Standard of National Committee for Clinical Laboratory(NCCLS),the minimal inhibi-tory concentrations(MIC) of Bp3 on 20 erythromycin-resistance staphylococcus aureus(ERSA) and its effects with erythromycin detected by microdilution method and checkerboard microdilution method.Results The inhibitory ef-fect of Bp3 on ERSA was better than erythromycin.When Bp3 and erythromycin were given i... |
| Keywords: | Traditional chinese medicine Monomers Erythromycin-resistant staphylococcus aureus Erythromycin In-vitro antibacterial activity |
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