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| 多沙普仑在中国回族和汉族健康人体内的药动学 | |
| 引用本文： | 肖勇,程佳,郭涛,夏东亚,郑谊,郭红亮.多沙普仑在中国回族和汉族健康人体内的药动学[J].药学服务与研究,2011,11(3):218-221. |
| 作者姓名： | 肖勇 程佳 郭涛 夏东亚 郑谊 郭红亮 |
| 作者单位： | 1. 解放军第五医院药剂科,银川,750004 2. 沈阳药科大学药学院临床药学教研室,沈阳,110016 3. 沈阳军区总医院药剂科,沈阳,110016 |
| 基金项目： | 全军医学科学技术研究"十一五"计划科技攻关课题基金资助项目 |
| 摘 要： | 目的:研究汉族和回族健康受试者单次静脉滴注盐酸多沙普仑后的药动学。方法:回族和汉族健康受试者各10名,单次静脉滴注盐酸多沙普仑50 mg,定时采血,用HPLC法测定多沙普仑血药浓度,DAS 2.0软件计算药动学参数。结果:回族受试者的主要药动学参数为:cmax(1.48±0.46)μg/mlt、1/2β(3.91±2.05)h、Vd(1.35±0.45)L/kg、AUC0~12(3.02±0.56)μg·h·ml-1、AUC0~∞(3.49±0.73)μg·h·ml-1。汉族受试者的主要药动学参数为:cmax(1.55±0.52)μg/mlt、1/2β(3.87±2.17)h、Vd(1.35±0.96)L/kg、AUC0~12(3.51±1.26)μg·h·ml-1、AUC0~∞(4.06±1.44)μg·h·ml-1。结论:经统计学分析,回族和汉族健康受试者单次静脉滴注盐酸多沙普仑后药动学参数的差异无统计学意义。 |
| 关 键 词： | 多沙普仑 药代动力学 汉族 回族 色谱法 高效液相 |
Pharmacokinetics of doxapram in Chinese Hui and Han healthy volunteers |
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| XIAO Yong,CHENG Jia,GUO Tao,XIA DongYa,ZHENG Yi,GUO HongLiang.Pharmacokinetics of doxapram in Chinese Hui and Han healthy volunteers[J].Pharmaceutical Care and Research,2011,11(3):218-221. | |
| Authors: | XIAO Yong CHENG Jia GUO Tao XIA DongYa ZHENG Yi GUO HongLiang |
| Institution: | XIAO Yong1,CHENG Jia2,GUO Tao3,XIA DongYa3,ZHENG Yi1,GUO HongLiang1(1.Department of Pharmacy,the 5th Hospital of PLA,Yinchuan 750004,China,2.Department of Clinical Pharmacy,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,3.Department of Pharmacy,the General Hospital of Shenyang Military Region,China) |
| Abstract: | Objective：To investigate the pharmacokinetics of doxapram in Chinese Hui and Han healthy volunteers.Methods：Ten Hui volunteers and ten Han volunteers were given a single dose of 50 mg doxapram by intravenous infusion.The concentration of doxapram in plasma was determined by HPLC method,and the pharmacokinetic parameters were calculated by DAS 2.0 software.Results：The main pharmacokinetic parameters of Hui volunteers were as follows： cmax（1.48±0.46） μg/ml,t1/2β（3.91±2.05） h,Vd（1.35±0.45） L/kg,AUC0-12（3.02±0.56） μg·h·ml-1,AUC0-∞（3.49±0.73） μg·h·ml-1.The main pharmacokinetic parameters of Han volunteers were as follows： cmax（1.55±0.52） μg/ml,t1/2β（3.87±2.17） h,Vd（1.35±0.96） L/kg,AUC0-12（3.51±1.26） μg·h·ml-1,AUC0-∞（4.06±1.44） μg·h·ml-1.Conclusion：There were no significant differencesin the pharmacokinetic parameters of doxapram between Chinese Hui and Han healthy volunteers. |
| Keywords: | doxapram pharmacokinetics Han nationality Hui nationality chromatography high performance liquid |
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