电针对血管性痴呆模型大鼠学习记忆能力的影响(英文)

目的:观察电针对血管性痴呆大鼠学习记忆能力的影响。方法:将72只SD大鼠随机分为4组,即正常组、假手术组、模型组和电针预处理组。采用改良线栓法制备血管性痴呆大鼠模型,观察电针对血管性痴呆大鼠Morris水迷宫的学习记忆能力。结果:模型组大鼠在水迷宫实验中的平均逃避潜伏期延长,与假手术组比较差异具有统计学意义(P0.01)。经电针预处理后,大鼠平均逃避潜伏期及定位航行试验成绩与模型组大鼠相比,差异有统计学意义(P0.01)。结论:电针预处理可以显著提高血管性痴呆大鼠的学习记忆能力。

Effect of electroacupuncture on learning and memory in rats with vascular dementia

Objective:To observe the effect of electroacupuncture on learning and memory in rats with vascular dementia.Methods:Seventy-two SD rats were randomly divided into 4 groups,a normal group,a sham operation group,a model group and an electroacupuncture (EA) pretreatment group.Modified intraluminal embolism method with nylon thread was applied to make rat model of vascular dementia,and the ability of learning and memory was observed in Morris water maze.Results:The average time of escape and latency in the rats of model group in the water maze test was prolonged,with significant difference compared with that in the sham group (P<0.01).The average time of escape and latency and navigation test results of rats pretreated by EA had statistically significant difference compared with those of the model group (P<0.01).Conclusion:EA pretreatment can significantly improve the ability of learning and memory of the rats with vascular dementia.