雷公藤甲素对类风湿关节炎滑膜新生血管中血管内皮生长因子、白细胞介素-6抑制机理的探讨

目的:了解雷公藤甲素对类风湿关节炎中血管内皮生长因子、白细胞介素-6的影响,探讨雷公藤对类风湿关节炎患者滑膜新生血管的抑制机理.方法:应用免疫组化技术检测血管内皮生长因子、白细胞介素-6在AA大鼠踝关节滑膜组织中的表达,并观察了雷公藤对其的影响.结果:雷公藤组可见少量的血管内皮生长因子阳性细胞,与对照组比较差异有统计学意义(P＜0.01).大鼠滑膜关节腔滑液中白细胞介素-6水平检测中,实验显示对照组滑膜组织中白细胞介素-6的水平明显高于空白组和雷公藤组(P＜0.01).结论:雷公藤甲素能降低滑膜组织血管内皮生长因子、白细胞介素-6的表达水平,抑制血管生成.

Inhibitory mechanism of Triptolide on the expression of VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel

Objective:To investigate the effect and inhibitory mechanisms of Triptolide on VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel.Methods:Use immunohistochemical techniques to detect expression of VEGF,IL-6 in the AA rats in the organization of the synovial organization,and to observe the effects of tripterygium wilfordii on the expression of VEGF,IL-6.Results:VEGF positive cells were visible in the tripterygium wilfordii group,there was significant difference(P<0.01) compared with the experimental group.In the rat synovial articular cavity synovial fluid IL-6 level detection,IL-6 level in the experimental group synovial organization is significantly higher than the level of blank and tripterygium wilfordii group(P<0.01).Conclusion:Triptolide can reduce the expression of VEGF and IL-6 in synovial organizations and inhibit angiogenesis.