潘生丁心肌声学造影估价冠脉储备的实验研究

将８条犬左旋支冠脉（ＬＣＸ）临床缩窄，于主动脉根部快速注入声振７６％复方泛影葡胺行心肌声学造影（ＭＣＥ），并结合潘生丁试验，探讨播生丁ＭＣＥ定量指标估价冠脉储备的价值。结果提示：潘生丁试验后ＬＣＸ血流量及后壁峰值呈下降趋势，而前壁峰值则呈上升趋势（Ｐ＞０．０５）；前、后壁潘生丁试验后与试验前峰值比间有显著差异；潘生丁试验后与试验前ＬＣＸ血流量比与后壁峰值比间无显著差异，两者间相关系数为０．６５。结论：ＭＣＥ潘生丁试验后与试验前峰值比能作为一项估价冠脉储备的指标。

Experimental Study on Assessment of Coronary Blood Flow Reserve by Dipyridamole Myocardial Contrast Echocardiography

According to the hypothesis that dipyridamole myocardial contrast echocardiography(MCE)could be used to assess coronary blood flow reserve,eight dogs had been operated upon to produce critical stenosis of the left circumflex coronary artery(LCX).Nine milliliters of sonicated Renografin-76 was injected into the aortic root before and after intravenous dipyridmole administration.The results showed that blood flow of LCX,peak contrast intensity from pesterior wall decreased insigniflcantly and peak contrast intensitv from anterior wall in-creased insignificantiy after dipyridamole injction. There were differel1ces between the ratios of peak amplitudes af-ter dipyridamole and before dipyridamole derived from two beds;There were no differences between the ratio of blood flow from the LCX and the ratio of peak amplitude from the posterior wall.There was a correlation between the two ratios cr=0.657.Conclusion:The ratio of peak amplitude after dipyridamole and before dipyridamole can be used to assess coronary blood flow reserve.