VitE对严重烧伤病人早期中性粒细胞吞噬功能损伤的防治作用

观察应用抗氧化剂ＶｉｔＥ对２２例大面积深度烧伤病人早期中性粒细胞吞噬功能损伤的防治作用。结果严重烧伤复苏后，非治疗组全血中超氧化物歧化酶（ＳＯＤ）含量下降，丙二醛（ＭＤＡ）值上升、中性粒细胞功能异常均较健康人组和ＶｉｔＥ治疗组显著：血浆过氧化脂质产物ＭＤＡ升高与中性粒细胞（ＰＭＮ）吞噬率，吞噬指数均呈显著负相关；而ＶｉｔＥ治疗组与对照组比较可见，治疗组ＳＯＤ下降，ＭＤＡ上升，ＰＭＮ功能下降均见减轻。结果提示，在严重烧伤早期复苏补液治疗中，应用自由基清除剂和抗氧化剂可防治严重烧伤后早期ＰＭＮ功能损伤程度，提高机体防御能力。有关适宜用药剂量尚待进一步探讨。

Protective effects of vitamin E on impaired neutrophil phagocytic function in patients with severe burn

The protective effects of vitamin E on impaired neutrophil phagocytic function were observed in 22 patients with severe burn.The results showed that lowering of SOD values, elevation of MDA values significantly elevated and impairment of neutrophil phagocytic function were all more marked in the patients who did not receive vitamin E than that of vitamin E treated groups and the healthy control.It was also found that there was a significant inverse correlation between MDA values of blood plasma and neutrophil phagocyte rate and phagocyte index in the patients without vitamin E treatment. The results suggested that in severely burned patients the use of free radical scavenger and antioxidant could protect the neutrophil function to certain extent.The optimal dosage of vitamin E will be further assessed.