| 大鼠脑干缺血模型制备及早期超微结构观察 |
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| 引用本文： | 张信,马春华,张彦宗,宫学华,黄益兴. 大鼠脑干缺血模型制备及早期超微结构观察[J]. 脑与神经疾病杂志, 2004, 12(5): 358-360,363 |
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| 作者姓名： | 张信 马春华 张彦宗 宫学华 黄益兴 |
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| 作者单位： | 065000,中国石油天然气集团公司中心医院急诊科;065000,中国石油天然气集团公司中心医院急诊科;065000,中国石油天然气集团公司中心医院急诊科;065000,中国石油天然气集团公司中心医院急诊科;065000,中国石油天然气集团公司中心医院急诊科 |
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| 摘 要： | 目的:制备脑干缺血动物模型并观察大鼠脑干缺血后早期组织学病理的超微结构。方法:应用两点电凝基底动脉的方法制作鼠脑干缺血动物模型。结果:病理学观察发现脑干缺血2小时即可出现超早期病理变化,并随时间的延长缺血性损害逐渐加重。结论:两点电凝基底动脉后可以造成稳定的脑干缺血,对急性脑干缺血的病理学研究有一定的价值。
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| 关 键 词： | 大鼠 脑干缺血 基底动脉 动物模型 病理 |
| 文章编号： | 1006-351X(2004)02-0358-03 |
Establishment of brainstem ischemic model and observations of early pathologic changes in rats |
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| ZHANG Xin,MA Chunghua,ZHANG Yanzong.. Establishment of brainstem ischemic model and observations of early pathologic changes in rats[J]. Journal of Brain and Nervous Diseases, 2004, 12(5): 358-360,363 |
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| Authors: | ZHANG Xin MA Chunghua ZHANG Yanzong. |
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| Abstract: | Objective: To establish brainstem ischemic model and to observe earlier period ultrastructure of histology and pathology after brainstem ischemia in rats. Method: The models were made by coagulated basilar artery at two points. Result: 2 hours after brainstem ischemia ultra-early changes of pathology were observed, lesions of ischemia was aggravated gradually along with the prolongation of time. Conclusion: Resistant brain stem ischemia can be got by coagulate basilar artery at two points, the model is suitable to study pathology of acute brain stem ischemia. |
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| Keywords: | rat brainstem ischemia basilar artery animal model pathology |
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