雷尼替丁治疗非典型抗精神病药所致体重增加疗效研究

目的：探讨雷尼替丁治疗非典型抗精神病药物所致体重增加的疗效。方法：对非典型抗精神病药物所致体重增加患者62例，在常规服用非经典抗精神病药物的同时给予雷尼替丁治疗，疗程8w，观察治疗前后体重、体重指数、腰围、臀围、腰／臀比值及胆固醇、三酰甘油的变化。结果：治疗8W后体重、体重指数、腰围、臀围、腰／臀比值均较治疗前有极显著下降（P〈0．01），TG、LDC—C、GIU均有显著下降（P〈0．05），HDL—C显著升高（P〈0．05）。结论：雷尼替丁对非经典抗精神病药物所致体重增加有显著的治疗效果，且不良反应少，安全性好。

Effect study for ranitidine in treatment of atypical antipsychotics-induced weight gain

Objective： To explore efficacy of ranitidine in treatment of atypical antipsychotics - induced weight gain. Methods：62 cases with atypical antipsychotics - induced weight gain were treated with ranitidine for 8 weeks besides the atypical antipsychotics. Body weight, body mass index, waist circumference, hip circumference, waist/hip ratio, cholesterol, and triglycerides were measured before and after the treatment. Results： After 8 weeks＇treatment, the body weight, body mass index, waist circumference, hip circum- ference and waist/hip ratio decreased significantly compared with those before the treatment （P 〈 0.01 ） ; moreover, triglycerides, low density lipoprotein, blood glucose and GIU were significantly lower than those before the treatment （P 〈 0.05）, whereas high density lipoprotein significantly increased（P 〈 0.05 ）. Conclusions： Ranitidine for treating atypical antipsychotics -induced weight gain has the advantages of obvious effects, a few side effects, and good safety.