| APE/Ref-1在消化系统肿瘤中的研究进展 |
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| 引用本文： | 宋军民,李琳,李岩. APE/Ref-1在消化系统肿瘤中的研究进展[J]. 胃肠病学, 2013, 18(6): 374-377 |
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| 作者姓名： | 宋军民 李琳 李岩 |
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| 作者单位： | 中国医科大学附属盛京医院消化内科,110004 |
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| 摘 要： | DNA碱基切除修复(BER)参与由各种原因导致的DNA损伤修复过程,是维持基因组DNA完整性的一个重要修复机制。脱嘌呤/脱嘧啶核酸内切酶/氧化还原因子-1(APE/Ref-1)是BER过程的关键酶之一,具有DNA修复、氧化还原激活、基因表达调控等多种生物学功能,近年研究显示APE/Ref-1与胃癌、结直肠癌、胰腺癌的发生关系密切。本文就APE/Ref-1在消化系统肿瘤中的研究进展作一综述。
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| 关 键 词： | DNA-(无嘌呤或无嘧啶位点)裂合酶 氧化还原因子-1 消化系统肿瘤 DNA修复 |
Advances in Study on APE/Ref-1 in Digestive System Tumors |
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| SONG Junmin , LI Lin , LI Yan. Advances in Study on APE/Ref-1 in Digestive System Tumors[J]. Chinese Journal of Gastroenterology, 2013, 18(6): 374-377 |
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| Authors: | SONG Junmin LI Lin LI Yan |
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| Affiliation: | .(Department of Gastroenterology,Shengjing Hospital of China Medical University,Shenyang(110004) ) |
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| Abstract: | DNA base excision repair（BER） is involved in the repair process of DNA damage due to all kinds of causes.It plays an important role in maintaining the integrity of genomic DNA.Apurinic / apyrimidinic endonuclease / redox factor-1（APE / Ref-1） is a key enzyme for BER.It has various biological functions such as DNA repair,oxidoreduction activation and regulation of gene expression.Recent studies demonstrated that APE / Ref-1 had a close association with gastric cancer,colorectal cancer and pancreatic cancer.This article reviewed the advances in study on APE / Ref-1 in digestive system tumor. |
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| Keywords: | DNA-(Apurinic or Apyrimidinic Site) Lyase Redox Factor-1 Digestive System Neoplasms DNA Repair |
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