灵芝冲剂对大鼠的长期毒性实验研究

目的观察连续灌胃灵芝冲剂对大鼠产生的毒性反应。方法灵芝冲剂1.5 g.kg-1、3.0 g.kg-1、6.0 g.kg-1连续灌胃26周,给药结束时测试大鼠体重、尿液、血液学常规、血液生化、脏器系数及病理组织学变化。结果各剂量组大鼠发育正常,各项检测结果未见与用药相关的异常变化,主要脏器病理组织学检查未见毒性病变。结论灵芝冲剂给予大鼠长期连续灌胃未见明显毒性反应,长期服用安全。

Study on the Long Term Toxicity of Ganoderma Lucidum Granule to Rats

Objective To observe the long term toxicity reaction of rats given Ganoderma Lucidum granule continuously. Methods The rats were randomly assigned to the control and three experimental groups, n=14 per group, equal number of male and female. Rats of three experimental groups were given Ganoderma Lucidum granule（ig） at dose of 1.5g·kg-1, 3.0g·kg-1, 6.0g·kg -1 for 26 weeks. The body weight, urine, hematology, plasma prothrombin time, blood biochemistry and ratio of viscera to body were measured at the end of experiment. At the same time, the major organs were examined by pathology. Results The results showed that the abnormity induced by Ganoderma Lucidum granule were not found in all experimental groups, and the development of rats were normal. Compared with the control group, the urine, hematology, plasma prothrombin time, blood biochemistry and ratio of viscera to body of drug taking groups showed no significant toxicological difference. The pathological examination discovered no obvious pathological changes relating to drug toxicity. Conclusion Our study shows that there is not toxicity of Ganoderma Lucidum granule given to rats for long term, and it is safe to administrate Ganoderma Lucidum granule continuously.