冠心病患者脂蛋白(a)同型半胱氨酸和超敏C反应蛋白的检测及临床意义

目的探讨血清脂蛋白[LP(a)]、同型半胱氨酸(Hcy)及超敏C反应蛋白(Hs-CRP)的检测在冠心病患者中的临床意义。方法对142例冠心病患者[稳定型心绞痛(SAP)58例、不稳定型心绞痛(UAP)49例、急性心肌梗死(AMI)35例]LP(a)、Hcy及Hs-CRP血清水平用免疫抑制法进行检测;并与正常对照组的50例健康体检者进行比较分析。结果冠心病组血清LP(a)、Hcy和Hs-CRP水平显著高于正常对照组,差异有统计学意义(P<0.01);SAP组和UAP组血清LP(a)、Hcy和Hs-CRP水平显著低于AMI组,差异有统计学意义(P<0.05);SAP组血清LP(a)、Hcy和Hs-CRP水平显著低于UAP组,差异有统计学意义(P<0.05);血清LP(a)、Hcy和Hs-CRP呈正相关(r=0.85,0.76,P<0.05)。结论冠心病患者血清LP(a)、Hcy和Hs-CRP水平对患者疾病诊断、治疗及判断预后具有重要意义。

The clinical significance of serum levels of lipoprotein a, homocysteine and high-sensitivity C-reactive protein in patients with coronary heart disease

Objective To discuss the clinical significance of serum levels of lipoprotein a,homocysteine(Hcy) and high-sensitivity C-reactive protein(Hs-CRP) in patients with coronary heart disease(CHD).Methods The serum levels of LP(a),Hcy and Hs-CRP of 142 CHD patients including 58 stable angor pectoris(SAP) patients,49 unstable angor pectoris(UAP) patients and 35 acute myocardial infarction(AMI)patients were measured by means of immune suppression method and compared with those of 50 healthy people as the normal control.Results The serum levels of LP(a),Hcy and Hs-CRP of CHD group were significantly higher than those of normal control group.The difference was statistically significant(P<0.01).The serum levels of LP(a),Hcy and Hs-CRP of SAP group and UAP group were significantly lower than those of the AMI group.The difference was statistically significant(P<0.05).The serum levels of LP(a),Hcy and Hs-CRP of SAP group were significantly lower than those of UAP group.The difference was statistically significant(P<0.05).The levels of LP(a),Hcy and Hs-CRP were positively correlated(r=0.85,0.76,P<0.05).Conclusion Detection of serum levels of LP(a),Hcy and Hs-CRP in CHD patients for disease diagnosis,treatment and prognosis is of great significance.