冠心病患者血清生长分化因子15C反应蛋白水平与冠状动脉病变程度的相关性分析

目的探讨不同类型冠心病患者的血清生长分化因子15(GDF-15)、C反应蛋白(CRP)的水平变化,与粥样硬化斑块稳定性和冠状动脉病变程度的关系。方法选择行冠状动脉造影检查的冠心病患者92例作为研究对象,根据冠状动脉造影结果及临床病史,分为22例稳定型心绞痛组(A组),25例不稳定型冠心病组(B组),25例心肌梗塞组(C组)及20例正常对比组(D组),每组均测量并比较血清中GDF-15、CRP水平,并且采用Gensini积分评定冠状动脉血管病变狭窄程度与GDF-15、CRP的相关性。结果 A组、B组、C组血清GDF-15水平均明显高于D组(P<0.05),B组血清GDF-15、CRP水平均明显高于A组、D组(P<0.05),C组血清GDF-15、CRP水平均明显高于A、B、D组(P<0.05);血清GDF-15、CRP水平和冠状动脉病变Gensini积分均有正相关性(P<0.05)。结论 GDF-15和CRP水平与冠状动脉粥样硬化斑块的不稳定性及冠状动脉病变程度有关,斑块越不稳定,病变越重、GDF-15和CRP水平越高,对判断冠心病患者的病情程度、发展和预后有重要作用。

A relation analysis between serum levels of differentiation factor 15 and C reactive protein in patients with different coronary heart diseases and the correlation with severity of coronary artery lesion

Objective To investigate the change of serum levels of growth differentiation factor 15(GDF-15) and C reactive protein(CRP) in patients with different coronary heart diseases(CHD),and its relationship with the stability of atherosclerotic plaque and severity of coronary artery lesions.Methods Ninety-two patients undergoing coronary angiography were included in the study.According to the coronary angiographic results and clinical history,the patients were divided into stable angina pectoris group(group A,n=22),unstable angina pectoris group(group B,n=25),acute myocardial infarction group(group C,n=25) and normal control group(group D,n=20).Serum levels of GDF-15 and CRP were determined and compared among different groups.The degree of coronary artery stenosis was assessed by Gensini score,and the correlation between serum levels of GDF-15,CRP and Gensini score was analyzed.Results The serum levels of GDF-15 in group A,B and C was significantly higher than that of group D(P<0.05).The serum levels of GDF-15 and CRP in group B were significantly higher than those of group A and D(P<0.05).The serum levels of GDF-15 and CRP in group C were significantly higher than those of group A,B and D(P<0.05).The serum level of GDF-15 and CRP was positively correlated with Gensini score(P<0.05).Conclusion The serum levels of GDF-15 and CRP are correlated with the instability of atherosclerotic plaque and degree of coronary artery lesion.Patients with instable atherosclerotic plaque and serious coronary artery lesion have a higher level of GDF-15 and CRP,which play an important role in judging the severity and prognosis in patients with coronary heart diseases.