| 缺氧诱导因子-1α在中耳胆脂瘤组织中的表达 |
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| 引用本文： | 刘洋,崔永华,俞琳琳,张平.缺氧诱导因子-1α在中耳胆脂瘤组织中的表达[J].临床耳鼻咽喉头颈外科杂志,2005,19(1):4-6. |
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| 作者姓名： | 刘洋 崔永华 俞琳琳 张平 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院耳鼻咽喉科,武汉,430030 |
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| 摘 要： | 目的:探讨缺氧诱导因子- 1α(HIF- 1α)在中耳胆脂瘤发病机制中的作用,检测其在中耳胆脂瘤和外 耳道正常上皮中的表达情况。方法:取31例中耳胆脂瘤和10例外耳道正常上皮标本,用免疫组织化学技术检测 HIF-1α蛋白的表达。结果:在中耳胆脂瘤中HIF-1α的表达较外耳道正常上皮明显增多(P<0.05)。结论:中耳 胆脂瘤中HIF-1α的表达显著升高,推测HIF-1在中耳胆脂瘤的发生、发展过程中具有极其重要的作用,并且缺 氧有可能是中耳胆脂瘤发病机制中的一个诱因。
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| 关 键 词： | 缺氧诱导因子-1α 胆脂瘤 中耳 |
| 文章编号： | 1001-1781(2005)01-0004-03 |
| 修稿时间： | 2004年7月11日 |
Expression of hypoxia-inducible factor-1α in middle ear cholesteatoma |
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| LIU Yang,CUI Yonghua,YU Linlin,ZHANG Ping.Expression of hypoxia-inducible factor-1α in middle ear cholesteatoma[J].Journal of Clinical Otorhinolaryngology,2005,19(1):4-6. |
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| Authors: | LIU Yang CUI Yonghua YU Linlin ZHANG Ping |
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| Institution: | Department of Otolaryngology, Tongji Hospital, Wuhan, 430030, China. yangliu616@yahoo.com.cn |
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| Abstract: | OBJECTIVE: To explore the pathogenetic mechanism of middle ear cholesteatoma, the aim of this study is to detect the expression of Hypoxia-inducible factor-1alpha in middle ear cholesteatoma and normal external ear canal skin. METHOD: We used the technology of immunohistochemistry to examine the expression of Hypoxia-inducible factor-1alpha in thirty-one middle ear cholesteatomas and ten samples of normal external ear canal skin. RESULT: The expression of HIF-1alpha was extremely higher in middle ear cholesteatomas than in normal external ear canal skin (P <0.05). CONCLUSION: We found that the higher expression of Hypoxia-inducible factor-1alpha in middle ear cholesteatomas, so we think that Hypoxia-inducible factor-1alpha play an important role in the pathogenetic process of middle ear cholesteatoma, and hypoxia may be an incentive in the pathogenetic mechanism of middle ear cholesteatoma. |
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