Cross tolerance or tachyphylaxis among various psychotomimetic agents on cats

DOM, 2,5-dimethoxy-4-methylamphetamine, a perception-distorting psychotomimetic agent, has been demonstrated to elicit a marked behavioral syndrome in cats. This syndrome is antagonized by a pretreatment of DOM. This tachyphylaxis has been examined to determine the ability of various other types of psychotomimetic agents to antagonize the DOM-induced syndrome. Mescaline and d-LSD but not 1-LSD could prevent the occurrence of the DOM-induced behavior. Ditran, tryptamine and d-amphetamine did not antagonize DOM. Thus it appears that the perception-distorting psychotomimetic agents exhibit either cross tachyphylaxis or cross tolerance and may share a common mechanism of action.