| 单硝酸异山梨酯口腔崩解片的制备及药剂学研究 |
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| 引用本文： | 赵楠,汤真,王艳萍,薛万俐. 单硝酸异山梨酯口腔崩解片的制备及药剂学研究[J]. 药学实践杂志, 2007, 25(2): 94-97 |
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| 作者姓名： | 赵楠 汤真 王艳萍 薛万俐 |
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| 作者单位： | 1. 延边大学药学院,吉林,延吉,133000
2. 中国人民解放军第208医院,吉林,长春,130062 |
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| 摘 要： | 目的:筛选单硝酸异山梨酯口腔崩解片的处方并考察片剂质量。方法:采用正交设计法筛选片剂处方,用HPLC法测定片剂的含量。结果:所得的优化处方为:MCC与L-HPC的比例为8:2(32%,8%),CC- Na为3%,甘露醇为15%,乳糖为31%。所得的片剂在20 s内完全崩解,1 min释药80%以上,口感良好。结论:选择合适的辅料,可以生产出崩解快、口感好,能够快速起效的口腔崩解片。
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| 关 键 词： | 单硝酸异山梨酯 口腔崩解片 正交设计 |
| 文章编号： | 1006-0111(2007)02-0094-04 |
| 收稿时间： | 2006-11-22 |
| 修稿时间： | 2006-11-22 |
Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets |
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| ZHAO Nan,TANG Zhen,WANG Yan-ping and XUE Wan-li. Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets[J]. The Journal of Pharmaceutical Practice, 2007, 25(2): 94-97 |
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| Authors: | ZHAO Nan TANG Zhen WANG Yan-ping XUE Wan-li |
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| Affiliation: | 1. The Pharmacy College of Yan Bian University, Yanji 133000, China; 2. No. 208 Hospital of PLA, Changchun, 130062,China |
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| Abstract: | Objective:To optimize the formulation of 5-ISMN orally disintegrating tablets,and inspect quality of prepared tablets. Methods:The orthogonal design was used and HPLC was used to determine the concentration.Results:Besides 5-ISMN,the tablets were composed of croscarmellose sodium 3%,mannite 15%,lactose 31%,MCC/L-HPC ratio was 8:2(32%,8%).The prepared tablets disintegrated completely in 20s,dissolved more than 80% in 2min and tasty fine.Conclusion:Choose properly excipients,we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption. |
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| Keywords: | 5-ISMN orally disintegrating tablet orthogonal design |
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