Transition metal- and catalyst-free one-pot green method for the synthesis of N-sulfonyl amidines via direct reaction of sulfonyl azides with amines |
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| Authors: | Babak Kaboudin Saeed Torabi Foad Kazemi Hiroshi Aoyama |
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| Affiliation: | Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45137-66731 Iran, +98 24 3315 3220 ; School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji Tokyo 192-0392 Japan |
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| Abstract: | In this report, a green synthesis of N-sulfonyl amidines via the direct reaction of tertiary or secondary amines with sulfonyl azides is described. Transition metal- and catalyst-free conditions were used for the synthesis of biologically important N-sulfonyl amidines. Further studies showed that the reaction proceeded via in situ aerobic oxidation of amines under reflux conditions.A green synthesis of N-sulfonyl amidines via the direct reaction of tertiary or secondary amines with sulfonyl azides. |
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