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Correction: A novel biocompatible,simvastatin-loaded,bone-targeting lipid nanocarrier for treating osteoporosis more effectively
Authors:Shan Tao  Shao-qing Chen  Wen-tao Zhou  Fang-ying Yu  Lu Bao  Guo-xi Qiu  Qing Qiao  Fu-qiang Hu  Jian-wei Wang  Hong Yuan
Institution:College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058 China, +86-136-06804049 ; Anesthesia Department, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, 3 Qingchun East Road, Hangzhou 310016 China ; Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009 China, Fax: +86-571-87022776, +86-159-58185118
Abstract:Correction for ‘A novel biocompatible, simvastatin-loaded, bone-targeting lipid nanocarrier for treating osteoporosis more effectively’ by Shan Tao et al., RSC Adv., 2020, 10, 20445–20459, DOI: 10.1039/D0RA00685H.

The authors regret that incorrect versions of Fig. 7, ,99 and and1010 were included in the original article. The correct versions of Fig. 7, ,99 and and1010 are presented below.Open in a separate windowFig. 7Histological analysis of organs from all experimental groups. H&E staining of heart, liver, spleen, lung, kidney, indicating the carrier has good biocompatibility. Scale bar = 50 μm.Open in a separate windowFig. 9Alkaline phosphatase (ALP) activity (arrows) and tartrate-resistant acid phosphatase (TRAP) assay results (arrowheads) of bone tissue sections. Scale bar = 50 μm. The ALP activity is much more high in SIM/LNPs and SIM/ASP6-LNPs groups, while the TRAP activity is the opposite.Open in a separate windowFig. 10Histological assessment of bone formation in all experimental groups. (A) HE staining of femur bone. Scale bar = 50 μm. Histology of bone in the all experimental groups shows all ovariectomized groups had a higher amount of adipose tissue than Sham group. The trabecular bone is much more prominent in SIM/LNPs and SIM/ASP6-LNPs groups. (B) Immunohistochemical staining for BMP-2 in typical newly-formed bone tissue (red arrows) and immunohistochemical staining for the osteogenic markers osteopontin (OPN, arrows) and osteocalcin (OCN, arrowheads). Scale bar = 50 μm. The BMP-2, OPN, OCN are much more prominent in SIM/LNPs and SIM/ASP6-LNPs groups.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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