Correction: A novel biocompatible,simvastatin-loaded,bone-targeting lipid nanocarrier for treating osteoporosis more effectively |
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Authors: | Shan Tao Shao-qing Chen Wen-tao Zhou Fang-ying Yu Lu Bao Guo-xi Qiu Qing Qiao Fu-qiang Hu Jian-wei Wang Hong Yuan |
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Institution: | College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058 China, +86-136-06804049 ; Anesthesia Department, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, 3 Qingchun East Road, Hangzhou 310016 China ; Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009 China, Fax: +86-571-87022776, +86-159-58185118 |
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Abstract: | Correction for ‘A novel biocompatible, simvastatin-loaded, bone-targeting lipid nanocarrier for treating osteoporosis more effectively’ by Shan Tao et al., RSC Adv., 2020, 10, 20445–20459, DOI: 10.1039/D0RA00685H.The authors regret that incorrect versions of , and were included in the original article. The correct versions of , and are presented below.Open in a separate windowHistological analysis of organs from all experimental groups. H&E staining of heart, liver, spleen, lung, kidney, indicating the carrier has good biocompatibility. Scale bar = 50 μm.Open in a separate windowAlkaline phosphatase (ALP) activity (arrows) and tartrate-resistant acid phosphatase (TRAP) assay results (arrowheads) of bone tissue sections. Scale bar = 50 μm. The ALP activity is much more high in SIM/LNPs and SIM/ASP6-LNPs groups, while the TRAP activity is the opposite.Open in a separate windowHistological assessment of bone formation in all experimental groups. (A) HE staining of femur bone. Scale bar = 50 μm. Histology of bone in the all experimental groups shows all ovariectomized groups had a higher amount of adipose tissue than Sham group. The trabecular bone is much more prominent in SIM/LNPs and SIM/ASP6-LNPs groups. (B) Immunohistochemical staining for BMP-2 in typical newly-formed bone tissue (red arrows) and immunohistochemical staining for the osteogenic markers osteopontin (OPN, arrows) and osteocalcin (OCN, arrowheads). Scale bar = 50 μm. The BMP-2, OPN, OCN are much more prominent in SIM/LNPs and SIM/ASP6-LNPs groups.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. |
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