Portable solid-state sensor for therapeutic monitoring of an antineoplastic drug; vinblastine in human plasma |
| |
Authors: | Maha Mohammed Galal Ahmed Sayed Saad |
| |
Institution: | Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, PO 11562, Cairo Egypt, +201117486474, +201004009443 ; Pharmaceutical Chemistry Department, School of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC), Badr City 11829 Cairo Egypt |
| |
Abstract: | During cancer treatment, doses must be carefully administered and monitored to guarantee efficacy and minimize side-effects. A potentiometric sensor was developed for the direct real-time assay of a widely used antineoplastic drug (vinblastine (VB)) in plasma samples. Membrane cocktails were drop-casted over a glassy-carbon electrode coated with a lipophilic conducting polymer (polyaniline). The study investigated five cation exchangers, five plasticizers (of different polarities and dielectric constants), and four ionophores with different physicochemical characters on the sensor performance. The study substantiates a data-driven selection of the optimum membrane recipe. The latter included sodium tetraphenylborate as an ion exchanger, dioctylphthalate as a plasticizer, and hydroxypropyl-β-cyclodextrin as ionophore. The membrane proved a near-Nernstian slope of 37.5 mV per decade, a LOQ of 2.99 × 10−6 M, and a stable fast response. The selectivity study proved poor responses to common physiological ions. The developed sensor was used for the determination of VB in its pure powder form, marketed formulation, and plasma samples. The fast and direct sensor response enables a wide range of applications in quality control laboratories and clinical studies.Potentiometric glassy carbon electrode for determination of vinblastine. |
| |
Keywords: | |
|
|