Direct sulfonamidation of (hetero)aromatic C–H bonds with sulfonyl azides: a novel and efficient route to N-(hetero)aryl sulfonamides |
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| Authors: | Zhi Liu Abdolghaffar Ebadi Mohsen Toughani Nihat Mert Esmail Vessally |
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| Affiliation: | School of Electrical and Automation Engineering, East China Jiaotong University, Nanchang 330013 China.; Department of Agriculture, Jouybar Branch, Islamic Azad University, Jouybar Iran.; Department of Fishery, Babol Branch, Islamic Azad University, Babol Iran.; Department of Biochemistry, Faculty of Veterinary Medicine, University of Yuzuncu Yil, 65080, Van Turkey.; Department of Chemistry, Payame Noor University, Tehran Iran, |
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| Abstract: | N-Aryl sulfonamides belong to a highly important class of organosulfur compounds which are found in a number of FDA-approved drugs such as dofetilide, dronedarone, ibutilide, sotalol, sulfadiazine, sulfamethizole, vemurafenib, and many more. There is therefore continuing interest in the development of novel and convenient protocols for the preparation of these pharmaceutically important compounds. Recently, direct sulfonamidation of (hetero)aromatic C–H bonds with easily available sulfonyl azides has emerged as an attractive and powerful strategy to access N-(hetero)aryl sulfonamides where non-toxic nitrogen gas forms as the sole by-product. This review highlights recent advances and developments (2012–2020) in this fast growing research area with emphasis on the mechanistic features of the reactions. N-Aryl sulfonamides belong to a highly important class of organosulfur compounds which are found in a number of FDA-approved drugs such as dofetilide, dronedarone, ibutilide, sotalol, sulfadiazine, sulfamethizole, vemurafenib, and many more. |
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