An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one via a cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1′-(arylmethylene)diurea |
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| Authors: | Yi-Cong Guo Xuan-Di Song Wei Deng Weidong Rao Haiyan Xu Zhi-Liang Shen |
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| Institution: | Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Jiangsu 211816 China.; Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037 China ; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang Jiangsu 212003 China, |
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| Abstract: | An efficient method for the synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one by using 1,1′-(arylmethylene)diurea and 1-aryl-2-propanone as substrates was developed. The reactions proceeded efficiently in the presence of Cs2CO3 to give the desired products in moderate to good yields with wide substrate scope and good functional group tolerance, serving as an attractive alternative or complement to the previously reported methods for the facile assembly of biologically and pharmaceutically active 3,4-dihydropyrimidin-2(1H)-ones.A Cs2CO3-promoted efficient method for the synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one by using 1,1′-(arylmethylene)diurea and 1-aryl-2-propanone as substrates was developed. |
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