Marine natural products from sponges (Porifera) of the order Dictyoceratida (2013 to 2019); a promising source for drug discovery |
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| Authors: | Enas Reda Abdelaleem Mamdouh Nabil Samy Samar Yehia Desoukey Miaomiao Liu Ronald J. Quinn Usama Ramadan Abdelmohsen |
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| Affiliation: | Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia Egypt.; Griffith Institute for Drug Discovery, Griffith University Brisbane, Queensland 4111 Australia ; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, 61111 New Minia City, Minia Egypt |
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| Abstract: | Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities. Sponges which belong to the order Dictyoceratida are distinctly classified into 5 families: Dysideidae, Irciniidae, Spongiidae, Thorectidae, and Verticilliitidae. In this review, compounds isolated from Dictyoceratida sponges were discussed with their biological potential within the period 2013 to December 2019. Moreover, analysis of the physicochemical properties of these marine natural products was investigated and the results showed that 78% of the compounds have oral bioavailability potential. This review highlights sponges of the order Dictyoceratida as exciting source for discovery of new drug leads.Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities. |
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