Early osteoblastic activity on TiO2 thin films decorated with flower-like hierarchical Au structures |
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Authors: | Spyridon Kalantzis,Salih Veziroglu,Theresa Kohlhaas,Christian Flö rke,Yogendra Kumar Mishra,Jö rg Wiltfang,Yahya Aç il,Franz Faupel,Oral Cenk Aktas,Aydin Gü lses |
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Abstract: | Titanium alloys are the most commonly used dental and orthopedic implant materials due to their proven biocompatibility and mechanical properties. The native oxide layer (TiO2 layer) formed on such Ti-based implants acts as the self-protecting layer against possible ion release. Increasing the oxide layer thickness further on such TiO2 implants even opens the triggering of the osseointegration process if the oxide layer is having a certain degree of roughness, preferably higher. This work reports a novel photocatalytic patterning of sputter deposited TiO2 layers with flower-like Au structures to enhance the early osteoblastic activity. The prepared hierarchical Au structures, composed of micro- and nanoscale features on the top, lead to improved number of filopodia formation. This suggest that proposed Au–TiO2 surface may foster the cell attachment and as well as cell proliferation.Flower-like hierarchical Au structures, composed of micro- and nanoscale features, lead to higher number of filopodia formation on TiO2 thin films. |
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