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目的观察全身应用卡铂、替尼泊苷和长春新碱(CTV)方案化疗加鞘内注射治疗脑脊液细胞学检查肿瘤细胞阳性的视网膜母细胞瘤(RB)患儿的疗效。方法6例患儿资料来自首都医科大学附属北京同仁医院2006年11月至2008年7月临床确诊为RB且治疗前行脑脊液细胞学检查发现肿瘤细胞者,对其进行6～9次CTV方案化疗加8～10次鞘内注射治疗,同时结合局部治疗,随访12～20个月,观察疗效。结果6例患儿均完成治疗,病情稳定,复查脑脊液细胞学检查均未发现肿瘤细胞,无复发及死亡。结论全身化疗加鞘内注射是对RB颅内转移有效的治疗方法,由于观察时间较短,长期疗效尚须行观察。

Curative effects of six patients with tumor cell of retinoblastoma found in cerebrospinal fluid

??Department of Pediatrics??Beijing Tongren Hospital affiliated to Capital University??Beijing 100730??China
Abstract??Objectives??To evaluate the effects of CTV ??carboplatin??Teniposide Vincristine?? chemotherapy and intrathecal chemotherapy in children with tumor cell of retinoblastoma in cerebrospinal fluid. Methods??Totally 256 cases who were clinically diagnosed with retinoblastoma in our hospital were studied?? 6 of them who had tumor cells in their cerebrospinal fluid before treatment were given 6??9 cycles of CTV??Carboplatine??Teniposide and Vincristine??chemotherapy and 8??10 times of intrathecal chemotherapy?? meanwhile?? focal therapy was performed. Follow-up was between 12 to 20 months. Results??All patients had completed the therapy?? up to now condition stable?? recheck the cerebrospinal fluid didn't show the tumor cell. Conclusion??System chemotherapy together with intrathecal chemotherapy is effective for children with tumor cell of retinoblastoma found in cerebrospinal fluid. However?? more patients with longer follow-up are needed to confirm these results.