妊高征患者血清和新生儿静脉血瘦素水平的研究

目的　探讨妊高征患者血清瘦素水平及其新生儿静脉血瘦素水平及其临床意义。方法　采用放射免疫分析法测定妊高征患者 3 0例、正常孕妇 2 0例及新生儿静脉血清瘦素的水平及正常未孕妇 2 0例血清瘦素水平。结果　中、重度妊高征组孕妇血清瘦素水平明显高于轻度妊高征组及正常孕妇组血清瘦素水平 ,差异非常显著 (P <0 .0 1) ,正常孕妇组血清瘦素水平明显高于未孕妇组血清瘦素水平 ,差异非常显著 (P <0 .0 1) ,轻度妊高征组血清瘦素明显高于正常未孕妇组 ,差异非常显著 (P <0 .0 1)。轻度妊高征患者与正常孕妇组相比较 ,差异无显著性 (P >0 .0 5 ) ;妊高征孕妇血清瘦素水平与新生儿静脉血瘦素水平呈正相关 (r =0 .0 3 ,P <0 .0 5 ) ,两组新生儿静脉血瘦素水平与新生儿体重呈显著正相关 ( r=0 .5 9,P <0 .0 1)。结论　孕妇血瘦素水平可作为监测妊高征病变及其严重程度及胎儿发育状况的一个潜在的临床指标

A study on maternal and neonatal serum leptin levels in patients with pregnancy-induced hypertension

Objective To investigate the levels of maternal and naonatal serum leptin in patients with pregnancy induced hypertension (PIH),and to evaluate its clinical significance in PIH.Methods The maternal and neonatal serum leptin levels were detected by radioimmunoassay in 30 patients with PIH,20 normal pregnant women and 20 nonpregnant women.Results In moderate and severe PIH,the levels of maternal serum leptin were significantly higher than those in mild PIH and normal pregnant women (P<0.01).There was a significant difference between normal pregnant women and nonpregnant women (P<0.01),and between mild PIH and nonpregnant women (P<0.01),but there was no significant difference between normal pregnant women and mild PIH (P>0.05).A negative correlation was observed between maternal and neonatal serum leptin levels in PIH group (r=0.03,P<0.05).A positive correlation was found between the neonatal serum leptin and neonatal weight in PIH women and normal pregnant women (r= 0.59, P<0.05).Conclusion The levels of maternal serum leptin may be used as a potential clinical marker to monitor the severe degree of PIH and the development condition of fetus.