尿肺炎链球菌抗原检测在儿童肺炎链球菌肺炎诊断中的临床意义

目的：探讨尿肺炎链球菌抗原检测在肺炎链球菌肺炎诊断中的临床意义。方法随机选择下呼吸道感染患儿300例，同时采集患儿痰标本、血标本、尿标本，对痰、血标本进行病原菌培养、鉴定，采用胶体金法检测尿肺炎链球菌抗原。结果300例患儿中，痰培养、血培养和尿肺炎链球菌抗原检测阳性率分别为10．33％（31/300）、15．67％（47/300）和19．33％（58/300），尿肺炎链球菌抗原检测阳性率高于其他两种方法，血培养检测阳性率高于痰培养（P＜0．05）；尿肺炎球链菌抗原检测诊断肺炎链球菌肺炎的灵敏度和特异度分别为82．98％（39/47）和92．49％（234/253）。结论尿肺炎链球菌抗原检测可作为儿童肺炎链球菌肺炎的辅助诊断依据。

Clinical significance of urinary Streptococcus pneumoniae antigen detection for the diagnosis of Streptococcus pneumoniae ;pneumonia in children

Objective To explore the clinical significance of urinary Streptococcus pneumoniae （Sp）antigen detection for the diagnosis of Sp pneumonia.Methods Sputum samples and blood samples,collected from 300 pediat-ric inpatients with lower respiratory tract infections,were detected for pathogenic bacteria by culture and identifica-tion,and urine samples,collected at the same time from the same inpatients,were detected for Sp antigen by colloidal gold method.Results Among 300 pediatric inpatients,the positive rates of sputum culture,blood culture and urinary Sp antigen test were 10.33%（31/300）,15.67%（47/300）and 19.33%（58/300）respectively.The positive rate of u-rinary Sp antigen test was higher than the other two methods,and the positive rate of blood culture was higher than sputum culture （P＆lt;0.05）.The sensitivity and specificity of the determination of urinary Sp antigen were 82.98%（39/47）and 92.49%（234/253）.Conclusion Urinary Sp antigen detection could be used for assisted diagnosis of Sp pneumonia in children.