齐拉西酮对精神分裂症患者心肌酶表达水平的影响 |
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引用本文: | 曾海深,周少雄,黎文应,朱进才.齐拉西酮对精神分裂症患者心肌酶表达水平的影响[J].检验医学与临床,2014,0(6):778-779. |
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作者姓名: | 曾海深 周少雄 黎文应 朱进才 |
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作者单位: | 曾海深 (广东省佛山市第三人民医院 528000); 周少雄 (广东省佛山市第三人民医院 528000); 黎文应 (广东省佛山市第三人民医院 528000); 朱进才 (广东省佛山市第三人民医院 528000); |
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摘 要: | 目的:探讨抗精神病药物齐拉西酮对精神分裂症患者心肌酶表达水平的影响。方法对63例精神分裂症患者进行齐拉西酮治疗,检测并比较治疗前后进行血清肌酸激酶(CK)、肌酸激酶同工酶MB(CK-MB)、乳酸脱氢酶(LD H )水平。结果精神分裂症患者齐拉西酮治疗后1周末、4周末、24周末上述血清心肌酶水平与治疗前比较差异有统计学意义(P<0.05)。结论长时间服用抗精神病药齐拉西酮可导致精神分裂症患者血清心肌酶代谢的异常。
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关 键 词: | 精神分裂症 齐拉西酮 心肌酶 |
Effect of ziprasidone on myocardial enzymes in patients with schizophrenia |
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Institution: | ZENG Hai-shen, ZHOU Shao-xiong, L I Wen-ying , ZHU J in-cai ( the Third People's Hospital of Foshan City, Foshan, Guangdong 528000, China ) |
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Abstract: | Objective To investigate the effect of ziprasidone on myocardial enzymes in patients with schizo-phrenia .Methods Serum levels of myocardial enzymes ,including creatine kinase (CK ) ,creatine kinase isozyme MB (CK-MB) and lactate dehydrogenase (LDH) ,were detected and compared in 63 cases of patients with schizophrenia before and after the therapy of ziprasidone .Results Serum levels of CK ,CK-MB and LDH in patient with schizo-phrenia detected at 1 ,4 and 24 weeks after the therapy of ziprasidone were statistically different with that detected before therapy (P<0 .05) .Conclusion Long-term therapy of ziprasidone could induce the abnormality of the metab-olism of serum myocardial enzymes . |
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Keywords: | schizophrenia ziprasidone myocardial enzymes |
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