不规则抗体筛查对提高临床输血安全的价值研究

目的：探讨输血前不规则血型抗体筛查对提高临床输血安全的意义。方法对2000例预输血患者进行抗体筛查，对不规则抗体筛查阳性的标本进行抗体特异性鉴定，统计不规则抗体的特异性和检出率。结果共筛出不规则抗体阳性者8例，阳性检出率为0．4％。其中血液系统疾病和肿瘤患者6例，占75．0％，高于其他疾病患者所占比例（2例，25．0％），比较差异有统计学意义（P＜0．05）。不规则抗体阳性患者抗体特异性鉴定结果显示， Rh系统抗体占62．5％，MNS系统抗体（抗-M抗体）占37．5％。结论输血前对患者进行不规则抗体检测，有利于选择适合患者的血液，有效减少或避免溶血性输血反应的发生，保证了患者的输血安全。

Study on the value of irregular antibody screening in clinical transfusion

Objective To investigate the value of irregular antibody screening in clinical blood transfusion. Methods 2 000 pre-transfusion patients underwent antibody screening were enrolled.Antibody specificity identifica-tion was performed for positive irregular specimens.Irregular antibody specificity and incidence were recorded.Re-sults There were 8 cases positive with irregular antibody,the positive rate was 0.4%,among which there were 6 patients with blood system diseases and tumors,accounting for 75.0%,higher than the proportion of patients with other diseases （2 cases,25.0%）,and the difference was statistically significant （P＆lt;0.05）.Irregular antibody speci-ficity identification indicated that Rh system antibodies accounted for 62.5%,and MNS system antibody （anti-M an-tibody）accounted for 37.5%.Conclusion Irregular antibody screening before blood transfusion might be helpful for choosing blood fit for patients,reducing or avoiding the occurrence of hemolytic transfusion reaction,and ensuing the safety of blood transfusion.