复方利福平胶囊致急性肾衰竭

1例29岁男性患者,因肺结核服用复方利福平胶囊（每粒含利福平600mg,异烟肼600mg）,1粒/次,隔日1次。治疗3个月后症状好转自行停药。1年后患者再次出现咳嗽、盗汗等症状,遂按原治疗剂量自行服用复方利福平胶囊。服药8d后,出现恶心、呕吐,腰痛,颜面及双下肢水肿,少尿、茶色尿。实验室检查：BUN21.2mmol/L,SCr877.8μmol/L,尿蛋白（＋）,尿潜血（＋＋＋）;ECT检查示左肾和右肾GFR值分别为21.11ml/min和20.98ml/min。停用复方利福平胶囊,行血液透析,同时给予对症、支持治疗,25d后症状好转。

Acute renal failure induced by compound rifampicin capsules

A 29-year-old man with tuberculosis received one capsule of compound rifampicin （each capsule contains rifampicin 600 mg and isoniazid 600 mg ） every other day. After 3 months of therapy,his symptoms improved and drug was stopped by himself. One year later,the patient developed cough,night sweats and other symptoms again. So he took compound rifampicin capsules at the above-mentioned therapeutic dosage by himself. After 8 days of treatment,nausea,vomiting,lumbago,edema of face and both lower extremities,decreased urine output,and dark urine appeared. Laboratory examinations revealed the following values：BUN 21.2 mmol/L,SCr 877.8 μmol/L,protein （＋）,and occult blood （＋ ＋ ＋）. On ECT test,his left and right kidneys showed GFR levels of 21.11 ml/min and 20.98 ml/min,respectively. Rifampicin was withdrawn and hemodialysis was given. Meanwhile he was treated with symptomatic and supportive therapies. Twenty-five days later,his symptoms improved.