兰索拉唑短程三联治疗幽门螺杆菌的疗效观察

目的：观察兰综拉唑联用克拉霉素及阿莫西林一周对幽门螺杆菌（HP）感染的十二脂肠溃疡病人疗效，方法：将83例胃镜正镜证实有HP感染十二指肠溃疡病人随机分成两组，A组30例，口服兰索拉唑30mg，阿莫西林500mg,克拉霉素500mg，用法每天二次，疗程一周，B组53例，口服兰索拉唑30mg，每天一次，阿莫西林500mg，甲硝唑200mg，每天四次，疗程两周，治疗四周后复查胃镜了解溃疡愈合及HP根除率，结果：HP根限率A组96．7％，高于B组77．4％（P＜0．05），溃疡愈合率A组93．3％，与B组92．5％相似（P＞0．05）。溃疡愈合率A组93．3％，与B组92．5％相似（P＞0．05），结论：兰索拉唑联用克拉素及阿莫西林一周是目前较理想根除HP治疗方案。

The effect of a short triple therapy with Lansoprazole for helicobacter pylori infection

Objective:WT5BZ]ST5BZ]To evaluate the effect of a new triple therapy with lansoprazole plas amoxicillin and clarithromycin for one week on the patients with Duodenal ulcer and Helicobacter Pylori(HP)infection.WT5HZ]Methods:WT5BZ]83 patients with Duodenal ulcer and HP infection,which were confirmed by endoscopy,Were randomly divided into 2 groups.Group A received lansoprazole 30mg bid ,amoxictllin 500mg bid and clarithromycin 500mg bid for one week,while group B received lamsoprazole 30mg qd,amoxicillin 500mg qid and metronidazole 200mg qid for two weeks.Four weeks after completion of therapy,we reviewed these patients by endoscopy to know the heal of ulcer and eradication rate of HP.WT5HZ]Results:WT5BZ]The eradication rate of group A(96.7%)was significantly higher than that of group B(77.4%,P<0.05).The ulcer heal rate of group A(93.3%)was similiar to that of group B(92.5%,P>0.05).WT5HZ]Conclusions:WT5BZ]one week therapy with lansoprazole amoxicillin and clarithromycin is an ideal treatment for eradication of Hp infection. WT5HZ]