| 应用FOLFOX4方案治疗进展期结直肠癌52例临床观察 |
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| 引用本文： | 高志海,安燚,高军,赵陆,王键,韩伟,刘烨.应用FOLFOX4方案治疗进展期结直肠癌52例临床观察[J].中国煤炭工业医学杂志,2010,13(3):323-324. |
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| 作者姓名： | 高志海 安燚 高军 赵陆 王键 韩伟 刘烨 |
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| 作者单位： | 北京市第六医院普外科,100007 |
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| 摘 要： | 目的评价FOLFOX4方案治疗进展期结直肠癌的疗效和毒性。方法奥沙利铂（艾克博康）130mg／m2，静滴6h，d1；亚叶酸钙（CF）200mg／m2，静滴2h，d1～5，5-Fu300mg／m2，静滴4h，d1～d5，CF滴完后使用。每21d为一周期，化疗3～6周期后进行疗效分析。结果全组52例患者，总有效率（CR＋PR）为44．23％，主要毒副反应为外周神经感觉异常、骨髓抑制、恶心呕吐和腹泻，多为Ⅰ～Ⅱ度。结论FOLOX4方案治疗进展期结直肠癌疗效高，毒副反应可以耐受。
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| 关 键 词： | 结直肠癌 进展期 化学治疗 奥沙利铂 |
CLINICAL OBSERVATION ON EFFICACY OF FOLFOX4 REGIMEN IN 52 CASES WITH ADVANCED COLORECTAL CANCER |
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| Gao Zhihai,An Yi,Gao Jun,et al..CLINICAL OBSERVATION ON EFFICACY OF FOLFOX4 REGIMEN IN 52 CASES WITH ADVANCED COLORECTAL CANCER[J].Chinese Journal of Coal Industry Medicine,2010,13(3):323-324. |
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| Authors: | Gao Zhihai An Yi Gao Jun |
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| Institution: | Gao Zhihai,An Yi,Gao Jun,et al.Department of General Surgery,Beijing No.6 Hospital,Beijing 100007,China |
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| Abstract: | Objective To evaluate the effect and toxicity of FOLFOX4 regimen in patients with advanced colorectal cancer. Methods Oxaliplatin 130mg/m2 iv infusion for 6 hours, d1; CF 200mg/m2 iv infusion for 2 hours followed by 5-FU 300mg/m2 iv infusion for 4 hours, d1-5. Every 3 weeks was a cycle. Patients were evaluated after 3-6 cycles. Results The overall response rate (CR+PR) was 44.23%, The side effects were commonly seen with mild neurosensory toxicity,mucitis suppression of bone marrow, diarrhea, nausea and vom... |
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| Keywords: | advanced colorectal cancer chemotherapy oxaliplatin |
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