乙型肝炎肝纤维化麻鸭球结膜微循环及血液流变学特点

目的:观察鸭乙型肝炎肝纤维化动物模型的球结膜微循环及血液流变学特点。方法:用鸭乙型肝炎病毒(DHBV)阳性血清反复攻击建立鸭乙型肝炎肝纤维化动物模型,并检测球结膜微循环、血液流变学指标,肝纤维化指标、肝脏病理组织学变化。结果:用DHBV反复攻击造模后,其病理组织学改变具有肝脏细胞炎症,肝纤维组织增生,血清肝纤维化指标升高(P<0.01),球结膜微循环明显障碍(P<0.01),血液流变学改变(P<0.01)。结论:乙型肝炎肝纤维化麻鸭具有明显的微循环障碍及血液流变学改变。

Characteristics of Bulbar Conjunctival Microcirculation and Blood Rheology in Hepatic Fibrosis Ducks Induced by DHBV

Aim: To observe the characteristics of bulbar conjunctivas microcirculation and blood rheology on experimental hepatic fibrosis in ducks. Methods: Ducks models with hepatic fibrosis were induced by duck hepatitis B vivns (DHBV) infection again and again and the bulbar conjunctivas micro circulation, change of liver histopathology and in- dexes of blood rheology and hepatic fibrosis were detected at the same time. Results: After DHBV repeated infection changes of liver histopathology had hepatocellular inflammation and proliferation of fibrour tissue. raise of serum hepatic fibrosis indexes (P<0. 01) , obvious microcirculatory disturbance and change of blood rheology (P<0. 01 ). Conclution: Duck models with DHBV has clear microcirculatory disturbance and blood rheology change.