替米沙坦治疗充血性心力衰竭的临床观察

目的 :观察替米沙坦治疗慢性充血性心力衰竭 （CHF）的临床疗效。方法 :经强心、利尿、扩血管等治疗 ,疗效不佳的 CHF患者 96例口服替米沙坦 4 0～ 80 mg,每天 1次 ,疗程 4周。观察治疗前后血压、心率、左室舒张末内径、左室射血分数以及心功能变化。结果 :4周治疗后血压、心率、左室舒张末内径均明显下降 （P<0 .0 5 ）。左室射血分数、心排出量、心脏排血指数等各项指标均明显增加 （P<0 .0 1） ,心功能改善 ,临床总有效率达 98% ,患者耐受性好。结论 ::替米沙坦治疗 CHF疗效好。

Efficacy of Telmisartan in treatment of congestive heart failure

AIM:To observe the efficacy of Telmisartan in treatment of congestive heart failure. METHODS:96 patient with heart failure, who had unsatisfactory results under conventional digitals, diuretics, vasodilators therapy, were given telmisartan 40-80mg orally once a day for 4 week. the changes of blood pressure (BP), heart rate (HR), left ventricular end diastolic dimension ( LVEDd), left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac index (CI) and cardiac function (NYHA) were observed. RESULTS:4 weeks after treatment, BP, HR and LVEDd decreased significantly (P<0.05) ; LVEF, CO, and CI increased (P<0.01), cardiac function (NYHA) improved 1-2 grade. Telmisartan had few adverse effects and patients tolerance was perfect. CONCLUSION :The efficacy of Telmisartan in treatment of congestive heart failure is satisfactory.