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| 双波长法测定凝胶剂中甲磺酸帕珠沙星的含量 | |
| 引用本文： | 张坤水,陈逸生,余楚钦,陈剑勇.双波长法测定凝胶剂中甲磺酸帕珠沙星的含量[J].中国当代医药,2011,18(26):50-51. |
| 作者姓名： | 张坤水 陈逸生 余楚钦 陈剑勇 |
| 作者单位： | 1. 中山大学孙逸仙纪念医院药学部,广东广州,510120 2. 中山大学附属第五医院临床药学部,广东珠海,519000 3. 广东药学院药物研究所,广东广州,510006 |
| 摘 要： | 目的：建立甲磺酸帕珠沙星凝胶中甲磺酸帕珠沙星含量的测定方法。方法：采用双波长紫外分光光度法,测定波长为247nm,参比波长为232nm,测得吸收度差值（ΔA）为定量依据。结果：甲磺酸帕珠沙星在3～10μg/ml浓度范围内线性良好,相关系数为0.9993,平均加样回收率为100.3%,RSD为1.4%（n=9）。结论：本方法测定甲磺酸帕珠沙星凝胶的含量,可消除辅料的干扰,其方法简便、快速、准确。 |
| 关 键 词： | 甲磺酸帕珠沙星 凝胶剂 双波长法 含量测定 |
Content determination of mesilate pazufloxacin in gel by double-wavelength spectrophotometry |
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| Authors: | ZHANG Kunshui CHEN Yisheng YU Chuqin CHEN Jianyong |
| Institution: | 1.Department of Pharmacy,Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Guangdong Province,Guangzhou 510120,China;2.Department of Pharmacy,Fifth Affiliated Hospital of Sun Yat-Sen University,Guangdong Province,Zhuhai 519000,China;3.Institute of Materia Medica,Guangdong College of Pharmacy,Guangdong Province,Guangzhou 510006,China |
| Abstract: | Objective：To set up a quantitative double-wavelength spectrophotometry method for the content determination of mesilate pazufloxacin in gel products.Methods：The double-wavelength,247 nm and 232 nm,spectrophotometry was used for determining the content of the mesilate pazufloxacin gel.Results：The linear ranges of Mesilate pazufloxacin was 3-10 μg/ml,r=0.999 3.The average recoveries was 100.3%,RSD=1.4%.Conclusion：The method can eliminate interference of excipient,and it is simple and accurate. |
| Keywords: | Mesilate Pazufloxacin Gel Double-wavelength Spectrophotometry Content determination |
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