辛伐他汀对冠心病患者血脂及c反应蛋白的影响

目的：探讨辛伐他汀对冠心病患者血脂及C反应蛋白（CRP）的影响。方法：将76例冠心病患者随机分为实验组40例,对照组36例。两组均予常规治疗,实验组加用辛伐他汀,20mg/Qn,治疗12周后评价两组患者血脂、CRP的变化,记录心血管事件发生率。结果：实验组能有效地降低总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）及CRP（P〈0.05）,实验组治疗后TC、LDL-C及CRP下降与对照组治疗后比较,差异有统计学意义（P〈0.05）,实验组的心血管事件发生率低于对照组（P〈0.05）。结论：辛伐他汀能明显降低冠心病患者CRP水平,抑制炎症反应,降脂效果好,可有效减少心血管事件的发生。

Effects of simvastatin on C-reactive protein and blood lipid level in patients with coronary heart disease

Objective：To detect the effect of simvastatin on C-reactive protein（CRP） and blood lipid level in patients with coronary heart disease.Methods：76 patients with coronary heart disease were randomly divided into experimental group（40 cases） and control group（36 cases）.All patients received conventional treatment.On the base of these measures,the experimental group received simvastatin 20 mg per night.All patients were treated for 12 weeks.TC,TG,LDL-C,HDL-C and CRP were observed.Adverse event was recorded.Results：TC,TG,LDL-C and CRP were all reduced in experimental group significantly（P〈0.05）.In the experimental group,TC,LDL-C and CRP were lower than that in control group（P〈0.05）.The adverse reaction with experimental group was lower than control group（P〈0.05）.Conclusion：Simvastatin can reduce CRP in patients with coronary heart disease.It can inhibit inflammation and has good effect on controlling blood lipid level.It is effective in reducing the potential exposure to cardiovascular events.