Uremic serum inhibits monocyte-dependent, but not interleukin-2-dependent steps of T cell proliferation |
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Authors: | H Dumann S C Meuer H K?hler |
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Institution: | I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universit?t, Mainz, FRG. |
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Abstract: | We examined the influence of uremic serum on antigen receptor triggered T cell proliferation in dialysis patients with impaired immune function, i.e., 12 nonresponders to hepatitis B vaccination. The dialysis patients showed a monocyte dysfunction and an increased responsiveness to interleukin 2 (IL-2) according to our previous findings. In vitro the addition of IL-2 completely reconstituted the defect. Uremic serum inhibited monocyte-dependent T cell proliferation of patients and of healthy controls. Contrary, monocyte-independent steps of T cell proliferation were not impaired by uremic serum. When IL-2 was added to cultures, the T cell proliferation in the presence of uremic serum was even enhanced. We conclude that uremic immunodeficiency may be enhanced by soluble factors present in uremic serum which inhibit monocyte-dependent steps of T cell proliferation. |
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