| 血管性痴呆小鼠海马神经元JNK的表达及意义 |
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| 引用本文： | 王雪笠,吕佩源,冯连元,张笋,甄宁,黄通瑞.血管性痴呆小鼠海马神经元JNK的表达及意义[J].实用医学杂志,2010,26(3). |
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| 作者姓名： | 王雪笠 吕佩源 冯连元 张笋 甄宁 黄通瑞 |
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| 作者单位： | 1. 白求恩国际和平医院神经内科,石家庄市,050082
2. 河北省人民医院神经内科,石家庄市,050000 |
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| 摘 要： | 目的:探讨血管性痴呆小鼠海马神经元JNK的表达及其意义.方法:应用双侧颈总动脉线结反复缺血一再灌注法制备血管性痴呆小鼠模型,并设正常组、假手术组、血管性痴呆模型组(模型组),利用跳台试验和水迷宫试验观测其行为学改变,应用免疫组化技术观测其海马神经元JNK的表达变化.结果:模型组小鼠与正常组、假手术组相比较,模型组小鼠学习成绩为跳台试验反应时间长,游全程时间长,错误次数多.记忆成绩为跳台试验潜伏时间短,游全程时间长,错误次数多(P＜0.05).海马的JNK免疫反应阳性细胞元免疫组化评分明显增加(P＜0.01).结论:血管性痴呆小鼠认知功能、记忆功能减退与JNK表达增加有关.
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| 关 键 词： | 血管性痴呆:JNK 免疫组化 |
Significance and expression of JNK in neuron of hippocampus in mice with vascular dementia |
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| WANG Xue-li,LV Pei-yuan,FENG Lion-yuan,ZHANG Sun,ZHEN Ning,HUANG Tong-Rui.Significance and expression of JNK in neuron of hippocampus in mice with vascular dementia[J].The Journal of Practical Medicine,2010,26(3). |
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| Authors: | WANG Xue-li LV Pei-yuan FENG Lion-yuan ZHANG Sun ZHEN Ning HUANG Tong-Rui |
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| Institution: | WANG Xue-li,LV Pei-yuan,FENG Lian-yuan,ZHANG Sun,ZHEN Ning,HUANG Tong-Rui.Department of Neurology,The Bethune international peace Hospital,Shijiazhuang 050082,China |
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| Abstract: | Objective To explore the expression and the significance of JNK in neuron of hippocampus in mice with vascular dementia(VD) and its role in the development of VD.Methods 66 mice were divided into three groups(the normal group,sham operation group,and the VD models group).The mice of VD models group were subjected to ischemia and reperfusion repeatedly by ligation of bilateral common carotid arteries to establish the VD models.The behavioral changes of the mice were investigated by step-down test and morris ... |
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| Keywords: | Dementia vascular JNK Immunohistochemical |
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