蒽环类药物对肿瘤患者心脏Tei指数影响的临床研究

目的探讨利用心肌做功指数(MPI,Tei指数)早期检测和评估蒽环类药物(ATC)对肿瘤患者心脏毒性的临床价值。方法用多普勒法测定46例恶性肿瘤患者ATC化疗前和化疗后3~6个月左心Tei指数,常规超声心动图EF、FS和E/A指标。结果与化疗前比较,Tei指数相关参数中ATC化疗后左心室等容舒张时间(IRT)延长,等容舒张指数(IRT/ET)增大,E/A指标降低(P<0.05)。左心室等容收缩时间(ICT),等容收缩指数(ICT/ET),EF和FS指标较化疗前无显著性差异。结论在早期评价ATC对肿瘤患者心脏功能损害方面,Tei指数、等容舒张指数是敏感的指标,E/A指标虽然在应用上有局限性,但也有一定参考意义。

A clinical research on Tei index in assessment of Myocardial Toxicity in cancer patients treated with anthracyclines

Objective To explore the clinical value of applying Tei index to assessing early cardiac function damage in cancer patients receiving cardiotoxic anthracycline chemotherapy.Methods Forty-six cancer patients treated with anthracycline chemotherapy were examined by echocardiography and Tei index,EF,FS and E/A were obtained by Doppler Method before chemotherapy and three～six months after chemotherapy.Results Parameters of Tei index showed that after chemotherapy,Left ventricular isovolumic relaxation time(IRT) was significantly prolonged,isovolumic relaxation index(IRT/ET) increased and E/A decreased(P<0.05).Left ventricular isovolumic contraction time(ICT),isovolumic contraction index(ICT/ET),EF and FS value had not significant difference.Conclusion Tei index and IRT/ET are two sensitive indicators in the early assessment of damage to the cardiac function of tumor patients caused by ATC,and E/A value has limitations in its application,but it still has certain reference value.