| NEOPLASTIC TRANSFORMATION OF HUMAN EMBRYONIC NASOPHARYNGEAL EPITHELIAL CELLS INDUCED BY N,N'-DINITROSOPIPERAZINE (DNP) IN VITRO |
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| 作者姓名： | 陈主初 潘世宬 姚开泰 |
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| 作者单位： | Cancer Research Laboratory，Hunan Medical University，Changsha，Cancer Research Laboratory，Hunan Medical University，Changsha，Cancer Research Laboratory，Hunan Medical University，Changsha |
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| 摘 要： | This experiment is the first report on N, N'-dini-trosopiperazine (DNF)-induced neoplastic transformation of human embryonic nasopharyngeal (HENPE) cells. The transformed cells showed a prolonged life span, anchorage independent growth, chromosome aberration, tumorigenicity and an altered cell morphological appearance. The results demonstrated that DNP was able to induce not only nasopharyngeal carcinoma (NPC) of rats in vivo, but also neoplastic transformation of HENPE cells in vitro.
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