| 滇丹参中酚酸类化学成分研究 |
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| 引用本文： | 张正付,陈鸿珊,李健蕊,蒋建东,李卓荣.滇丹参中酚酸类化学成分研究[J].中国中药杂志,2007,32(18):1886-1890. |
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| 作者姓名： | 张正付 陈鸿珊 李健蕊 蒋建东 李卓荣 |
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| 作者单位： | 中国医学科学院,北京协和医学院,医药生物技术研究所,北京,100050 |
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| 基金项目： | 国家重大专题创新药物中药现代化 |
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| 摘 要： | 目的：研究滇丹参Salvia yunnansis根中的化学成分。方法：采用水提取,经Diaion HP20大孔吸附树脂、Sephadex LH-20凝胶、ODS等柱色谱,对滇丹参中的酚酸类成分进行分离纯化,运用现代波谱技术鉴定化合物的结构。结果：从滇丹参中分离并鉴定了12个酚酸类化合物,分别为原儿茶醛(1),咖啡酸(2),阿魏酸(3),迷迭香酸(4),丹酚酸A(5),丹酚酸C(6),紫草酸(7),紫草酸B(8),9′-紫草酸B甲酯(9),9-紫草酸B甲酯(10),9′,9-紫草酸B二甲酯(11),9′-紫草酸B乙酯(12)。结论：化合物1,2,3,5,6,9,10,11,12为首次从该植物中分离。
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| 关 键 词： | 鼠尾草属 滇丹参 酚酸类成分 |
| 文章编号： | 1001-5302（2007）18-1886-05 |
| 收稿时间： | 2006-11-15 |
| 修稿时间： | 2006年11月15 |
Studies on polyphenolic chemical constitutents from root of Salvia yunnansis |
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| ZHANG Zheng-fu; CHEN Hong-shan; LI Jian-rui; JIANG Jian-dong; LI Zhuo-rong.Studies on polyphenolic chemical constitutents from root of Salvia yunnansis[J].China Journal of Chinese Materia Medica,2007,32(18):1886-1890. |
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| Authors: | ZHANG Zheng-fu; CHEN Hong-shan; LI Jian-rui; JIANG Jian-dong; LI Zhuo-rong |
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| Institution: | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050, China |
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| Abstract: | OBJECTIVE: To study the chemical constituents in the root of Salvia yunnansis. METHOD: Compounds were isolated and purified by Diaion HP20, Sephadex LH - 20, ODS chromatography. Their structures were determined by spectral analysis and chemical evidence. RESULT: Twelve compounds were isolated and identified from the root of S. yunnansis protocatechaldehyde (1), caffeic acid (2), ferulic acid (3), rosmarinic acid (4), salvianolic acid A (5), salvianolic acid C (6), lithospermicacid (7), lithospermicacid B (8), 9'-methyl lithospermate B (9), 9"'-methyl lithospermate B (10), 9',9'-dimethyl lithospermate B (11), 9'-ethyl lithospermate B (12). CONCLUSION: The compounds 1, 2, 3, 5, 6, 9, 10, 11 and 12 were first isolated from S. yunnanensis. |
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| Keywords: | Salvia Salvia yunnansis polyphenols |
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