| 虎杖甙对大鼠血管平滑肌细胞膜电位的影响 |
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| 引用本文： | 金春华,赵克森.虎杖甙对大鼠血管平滑肌细胞膜电位的影响[J].南方医科大学学报,1998(3). |
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| 作者姓名： | 金春华 赵克森 |
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| 作者单位： | Jin Chunhua，Zhao Kesen Deparmtnet of Pathophysiology，First Military Medical University，Guangzhou，510515 |
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| 摘 要： | 利用荧光染料和粘附式细胞仪观察虎杖甙（ＰＤ）对大鼠ＶＳＭＣ膜电位的影响。结果显示，给ＰＤ（０．４ｍｍｏｌ／Ｌ）５ｍｉｎ后，ＶＳＭＣ膜电位出现去极化。α肾上腺素能受体拮抗剂利及丁、组织胺受体拮抗剂甲氰咪胍和钙通道阻断剂维拉帕米分别预处理并不能阻断ＰＤ的去极化作用；但加入钠通道阻断剂河豚毒素（２μｍｏｌ／Ｌ）和钾通道阻断剂优降糖（２．５μｍｏｌ／Ｌ）都能显著抑制ＰＤ的去极化作用。提示ＰＤ使正常细胞膜去极化作用可能与钠、钾通道开放有关，并可能受α肾上腺素能受体、组织胺受体及钙通道的调节
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| 关 键 词： | 血管平滑肌 膜电位 大鼠 |
The effect of Polydatin on membrane potential of cultured vascular smooth muscle cells of rat |
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| Jin Chunhua,Zhao Kesen Deparmtnet of Pathophysiology,First Military Medical University,Guangzhou.The effect of Polydatin on membrane potential of cultured vascular smooth muscle cells of rat[J].Journal of Southern Medical University,1998(3). |
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| Authors: | Jin Chunhua Zhao Kesen Deparmtnet of Pathophysiology First Military Medical University Guangzhou |
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| Institution: | Jin Chunhua,Zhao Kesen Deparmtnet of Pathophysiology,First Military Medical University,Guangzhou,510515 |
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| Abstract: | |
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| Keywords: | Polydatin vascular smooth muscle cells membrane potential rats depolarization |
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