| 5-对氯苯基-1-正丁基-3-吡唑烷酮的合成及抗惊厥作用研究 |
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| 引用本文： | 全哲山,宋宗洙,朴虎日. 5-对氯苯基-1-正丁基-3-吡唑烷酮的合成及抗惊厥作用研究[J]. 延边医学院学报, 1992, 0(2) |
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| 作者姓名： | 全哲山 宋宗洙 朴虎日 |
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| 作者单位： | 延边医学院药化教研室，延边医学院药化教研室，延边医学院药化教研室 |
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| 摘 要： | 根据3-吡唑烷酮类化合物的定量构效关系,预测5-取代1-正丁基-3-吡唑烷酮类化合物的1位和5位取代基疏水性参数之和Fr约为5.6的化合物,可能具有较强的抗惊厥活性。为此,合成了具备这个条件的化合物5-对氯苯基-1-正丁基-3-吡唑烷酮,药理实验结果与预测相符,具有较强的抗惊厥活性,其ED_(50)为9.1mg/kg。
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| 关 键 词： | 吡唑烷酮类 合成 抗癫痫剂 |
Synthesis of 5-Chlorophenyl-1-Butyl-3-Pyrazolidinones and its Anticonvulsant Activity |
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| Quan Zheshan,Song Zongzu,Piao Hurl. Synthesis of 5-Chlorophenyl-1-Butyl-3-Pyrazolidinones and its Anticonvulsant Activity[J]. Journal of Medical Science Yanbian University, 1992, 0(2) |
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| Authors: | Quan Zheshan Song Zongzu Piao Hurl |
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| Affiliation: | Department of Medicinal Chemistry |
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| Abstract: | According to the quantitative structure-activity relationship of 1, 5-substituted-3-pyrazolidinones previously synthesized by others, stronger anticonvulsant activity of the compound having ∑Fr5.6 were forecasted and such synthesized compound, 5-(4-chlorophenyl)-1-butyl3-pyrazolidinone, showed the perdicted pharmacological activity and gave ED_(50)=9.1mg/kg. |
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| Keywords: | pyrazolidinone synthesis anticonvulsants |
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