FOLIC ACID AND THE HALF-LIFE OF DIPHENYLHYDANTOIN IN MAN |
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| Authors: | P. Buch Andreasen,J. Mø lholm Hansen,L. Skovsted,K. Siersbæ k-Nielsen |
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| Affiliation: | Medical Department F, Københavns Amtssygehus i Gentofte, Hellerup, Denmark.;Rledical Department A, Rigshospitalet, Copenhagen, Denmark. |
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| Abstract: | The half-life of diphenylhydantoin in man was investigated before and after treatment with high doses of folic acid and no significant changes were found. It thus seems unlikely that the possible influence of folic acid on diphenylhydantoin metabolism is mediated by an increased liver metabolism; the possibility, however, remains that the pattern of diphenylhydantoin-metabolites are altered. |
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