早期动脉粥样硬化血管造影征象的实验研究

探讨早期动脉粥样硬化的血管造影征象，以达到临床早期诊断，预防及治疗。材料与方法，（１）采用雄性新西兰白兔２０只，每只２ｋｇ，均为３月龄，随机分Ａ、Ｂ两组，Ａ组为普通料喂养，作为对照组；Ｂ组用含１％胆固醇免饲料喂养，作为高胆固醇血症，早期动脉粥样硬化模型；喂养时间均为１０周；

Experimental Study of Value of Angiography in the Diagnosis of Early Atherosclerosis

Objective: To evaluate value of angiography in the diagnosis of early atherosclerosis. Materials and Methods: Twenty male New Zealand white rabbits were divided into two groups. Rabbits in group A were fed a standard diet, in group B were fed diet with 1% cholesterol for 10 weeks. At the end of the dietary intervention, femoral artery angiography was made before and after infusion of acetylcholine (ACH), partial femoral arterial rinds were obtained for electron microscopic examination. Results: Electron microscopy revealed adherent monocyte, lipid-deposition in the intima, subjacent media and migration of smooth muscle cell in group B. There were no these changements in group A. ACH caused vasoconstriction of femoral arteries that were angiographically normal in group B. In constrast, vasodilation in femoral arteries in group A after use of ACH were observed. Conclusion: ACH-induced vasoconstriction of angiographycally normal vessels provides an useful method to diagnose early atherosclerosis.